Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLP1R, BDNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neuroinflammation | debate_co_mention | process | 0.45 |
| NLRP3 | debate_co_mention | gene | 0.45 |
| NLRP3, CASP1, IL1B, PYCARD | debate_co_mention | gene | 0.45 |
| SNCA | debate_co_mention | gene | 0.45 |
| neurodegeneration | associated_with | disease | 0.40 |
| neurodegeneration | implicated_in | disease | 0.40 |
| NLRP3, CASP1, IL1B, PYCARD | co_associated_with | gene | 0.40 |
| SNCA, HSPA1A, DNMT1 | co_associated_with | gene | 0.40 |
| TH, AADC | co_associated_with | gene | 0.40 |
| TLR4, SNCA | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:GLP1R, BDNF | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-ee1df336 | targets | hypothesis | 0.50 |
| AHR, IL10, TGFB1 | debate_co_mention | gene | 0.45 |
| CLDN1, OCLN, ZO1, MLCK | debate_co_mention | gene | 0.45 |
| GLP1R | debate_co_mention | gene | 0.45 |
| CLDN1, OCLN, ZO1, MLCK | co_associated_with | gene | 0.40 |
| AHR, IL10, TGFB1 | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:GLP1R, BDNF | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Vagal Afferent Microbial Signal Modulation | 0.521 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists [PMID:39865816] | Sharafshah A, Lewandrowski KU, Gold MS, | Current neuropharmacology | 2025 | 1 |
| Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alc [PMID:38509197] | ["Cruz B", "Vozella V", "Borgonetti V", | Molecular psychiatry | 2024 | 1 |
| Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling. [PMID:39737892] | ["Feetham CH", "Collabolletta V", "Worth | Nature communications | 2024 | 1 |
| The microbiome and eating disorders: a new framework at the interface of interoc [PMID:41921818] | ["Ziade I", "McDermott M", "O'Riordan K" | Neuroscience | 2026 | 0 |
| Liraglutide Attenuates Atorvastatin-Induced Hepatotoxicity by Restoring GLP-1R E [PMID:40711038] | ["Elsiad E", "Abd El Aal H", "Salem H", | Toxics | 2025 | 0 |
| The potential role of Tirzepatide as adjuvant therapy in countering colistin-ind [PMID:38788447] | ["Hassan N", "Ragab D", "Ibrahim S", "Ab | International immunopharmacolo | 2024 | 0 |
| The effects of Fc fusion protein glucagon-like peptide-1 and glucagon dual recep [PMID:38518602] | ["Jiang P", "Zeng Y", "Yang W", "Li L", | Biomedicine & pharmacotherapy | 2024 | 0 |
| Comparative effects of glucagon-like peptide-1 receptor agonists and sodium-gluc [PMID:39217337] | ["Albulushi A", "Tanoh D", "Almustafa A" | Cardiovascular diabetology | 2024 | 0 |
| The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term [PMID:37673050] | ["Cao T", "Wang L", "Jiao S", "Chen H", | Neuropsychobiology | 2023 | 0 |
| Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implica [PMID:36372278] | Kopp KO, Glotfelty EJ, Li Y, Greig NH | Pharmacological research | 2022 | 0 |
| The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkin [PMID:36117625] | ["Reich N", "H\u00f6lscher C"] | Frontiers in neuroscience | 2022 | 0 |
| Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteobl [PMID:34943934] | ["Zheng Y", "Xiao Y", "Zhang D", "Zhang | Cells | 2021 | 0 |
| The protective effect of Geniposide on diabetic cognitive impairment through BTK [PMID:31811349] | ["Liu S", "Zheng M", "Li Y", "He L", "Ch | Psychopharmacology | 2020 | 0 |
| Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases [PMID:30877973] | ["Dinda B", "Dinda M", "Kulsi G", "Chakr | European journal of medicinal | 2019 | 0 |
| Management of Diabetes Mellitus in Normal Renal Function, Renal Dysfunction and [PMID:31261624] | ["Tsai S", "Chen C"] | International journal of molec | 2019 | 0 |
| The adiponectin promoter activator NP-1 induces high levels of circulating TNFα [PMID:29959379] | ["Decara J", "Serrano A", "Pav\u00f3n F" | Scientific reports | 2018 | 0 |
| Assignment of Weight-Based Antibody Units for Seven Additional Serotypes to a Hu [PMID:26354860] | ["Goldblatt D", "Tan C", "Burbidge P", " | Clinical and vaccine immunolog | 2015 | 0 |
| Dendritic spine abnormalities in amyloid precursor protein transgenic mice demon [PMID:16079410] | ["Spires T", "Meyer-Luehmann M", "Stern | The Journal of neuroscience : | 2005 | 0 |